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1

Structure and Function of HIV-1 Reverse Transcriptase: Molecular Mechanisms of Polymerization and Inhibition

Stefan G. Sarafianos, Bruno Marchand, Kalyan Das, Daniel M. Himmel, Michael A. Parniak, Stephen H. Hughes, Eddy Arnold

Journal:

Journal of Molecular Biology

Année:

2009

Langue:

english

Fichier:

PDF, 918 KB

english, 2009

2

Reverse transcriptase in motion: Conformational dynamics of enzyme–substrate interactions

Matthias Götte, Jason W. Rausch, Bruno Marchand, Stefan Sarafianos, Stuart F.J. Le Grice

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Année:

2010

Langue:

english

Fichier:

PDF, 1.83 MB

english, 2010

3

Similarities and differences in the RNase H activities of human immunodeficiency virus type 1 reverse transcriptase and moloney murine leukemia virus reverse transcriptase

Hong-Qiang Gao, Stefan G Sarafianos, Edward Arnold, Stephen H Hughes

Journal:

Journal of Molecular Biology

Année:

1999

Langue:

english

Fichier:

PDF, 622 KB

english, 1999

4

Future treatment strategies for novel Middle East respiratory syndrome coronavirus infection

Adedeji, Adeyemi O, Sarafianos, Stefan G

Journal:

Future Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 922 KB

english, 2013

5

Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase

Singh, Kamalendra, Marchand, Bruno, Kirby, Karen A., Michailidis, Eleftherios, Sarafianos, Stefan G.

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 2.64 MB

english, 2010

6

Drug Resistance in Non-B Subtype HIV-1: Impact of HIV-1 Reverse Transcriptase Inhibitors

Singh, Kamalendra, Flores, Jacqueline, Kirby, Karen, Neogi, Ujjwal, Sonnerborg, Anders, Hachiya, Atsuko, Das, Kalyan, Arnold, Eddy, McArthur, Carole, Parniak, Michael, Sarafianos, Stefan

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 2.22 MB

english, 2014

7

Remembering Professor Walter A. Scott

Sarafianos, Stefan

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 223 KB

english, 2014

8

Design, Synthesis and Biological Evaluations of Hydroxypyridone Carboxylic Acids as Inhibitors of HIV Reverse Transcriptase-Associated RNase H

kankanala, jayakanth, Kirby, Karen A., Liu, Feng, Miller, Lena G., Nagy, Eva, Wilson, Daniel J., Parniak, Michael A, Sarafianos, Stefan G., Wang, Zhengqiang

Journal:

Journal of Medicinal Chemistry

Année:

2016

Langue:

english

Fichier:

PDF, 1.12 MB

english, 2016

9

Visualization of HIV-1 RNA Transcription from Integrated HIV-1 DNA in Reactivated Latently Infected Cells

Ukah, Obiaara, Puray-Chavez, Maritza, Tedbury, Philip, Herschhorn, Alon, Sodroski, Joseph, Sarafianos, Stefan

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 2.00 MB

english, 2018

10

5-Aminothiophene-2,4-dicarboxamide analogues as hepatitis B virus capsid assembly effectors

Tang, Jing, Huber, Andrew D., Pineda, Dallas L., Boschert, Kelsey N., Wolf, Jennifer J., Kankanala, Jayakanth, Xie, Jiashu, Sarafianos, Stefan G., Wang, Zhengqiang

Journal:

European Journal of Medicinal Chemistry

Année:

2018

Langue:

english

Fichier:

PDF, 1.30 MB

english, 2018

11

Synthesis of boranoate, selenoate, and thioate analogs of AZTp4A and Ap4A

Qianwei Han, Stefan G. Sarafianos, Eddy Arnold, Michael A. Parniak, Barbara L. Gaffney, Roger A. Jones

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 266 KB

english, 2009

12

Touching the heart of HIV-1 drug resistance: the fingers close down on the dNTP at the polymerase active site

Stefan G. Sarafianos, Kalyan Dasi, Jianping Dingi, Paul L. Boyer, Stephen H. Hughes, Edward Arnold

Journal:

Chemistry & Biology

Année:

1999

Langue:

english

Fichier:

PDF, 3.64 MB

english, 1999

13

Molecular biology: An HIV secret uncovered

Arnold, Eddy, Sarafianos, Stefan G.

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 451 KB

english, 2008

14

Structures of HIV-1 RT–DNA complexes before and after incorporation of the anti-AIDS drug tenofovir

Tuske, Steve, Sarafianos, Stefan G, Clark, Arthur D, Ding, Jianping, Naeger, Lisa K, White, Kirsten L, Miller, Michael D, Gibbs, Craig S, Boyer, Paul L, Clark, Patrick

Journal:

Nature Structural and Molecular Biology

Année:

2004

Langue:

english

Fichier:

PDF, 839 KB

english, 2004

15

Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA

Sarafianos, Stefan G., Das, Kalyan, Tantillo, Chris, Clark, Arthur D., Ding, Jianping, Whitcomb, Jeannette M., Boyer, Paul L., Hughes, Stephen H., Arnold, Edward

Journal:

The EMBO Journal

Année:

2001

Langue:

english

Fichier:

PDF, 604 KB

english, 2001

16

Clinical relevance of substitutions in the connection subdomain and RNase H domain of HIV-1 reverse transcriptase from a cohort of antiretroviral treatment-naïve patients

Atsuko Hachiya, Kazuki Shimane, Stefan G. Sarafianos, Eiichi N. Kodama, Yasuko Sakagami, Fujie Negishi, Hirokazu Koizumi, Hiroyuki Gatanaga, Masao Matsuoka, Masafumi Takiguchi, Shinichi Oka

Journal:

Antiviral Research

Année:

2009

Langue:

english

Fichier:

PDF, 472 KB

english, 2009

17

Taking aim at a moving target: designing drugs to inhibit drug-resistant HIV-1 reverse transcriptases

Stefan G Sarafianos, Kalyan Das, Stephen H Hughes, Eddy Arnold

Journal:

Current Opinion in Structural Biology

Année:

2004

Langue:

english

Fichier:

PDF, 450 KB

english, 2004

18

Expression, purification, and characterization of SARS coronavirus RNA polymerase

Ao Cheng, Wei Zhang, Youhua Xie, Weihong Jiang, Eddy Arnold, Stefan G. Sarafianos, Jianping Ding

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 1.01 MB

english, 2005

19

Combining mutations in HIV-1 reverse transcriptase with mutations in the HIV-1 polypurine tract affects RNase H cleavages involved in PPT utilization

Mary Jane McWilliams, John G. Julias, Stefan G. Sarafianos, W. Gregory Alvord, Eddy Arnold, Stephen H. Hughes

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 519 KB

english, 2006

20

The mutation T477A in HIV-1 reverse transcriptase (RT) restores normal proteolytic processing of RT in virus with Gag-Pol mutated in the p51-RNH cleavage site

Michael E Abram, Stefan G Sarafianos, Michael A Parniak

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 1.10 MB

english, 2010

21

Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody fab fragment at 2.8 Å resolution

Jianping Ding, Kalyan Das, Yu Hsiou, Stefan G Sarafianos, Arthur D Clark Jr, Alfredo Jacobo-Molina, Chris Tantillo, Stephen H Hughes, Edward Arnold

Journal:

Journal of Molecular Biology

Année:

1998

Langue:

english

Fichier:

PDF, 1.50 MB

english, 1998

22

The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase

Hong-Qiang Gao, Paul L Boyer, Stefan G Sarafianos, Edward Arnold, Stephen H Hughes

Journal:

Journal of Molecular Biology

Année:

2000

Langue:

english

Fichier:

PDF, 614 KB

english, 2000

23

Designing anti-AIDS drugs targeting the major mechanism of HIV-1 RT resistance to nucleoside analog drugs

Stefan G Sarafianos, Stephen H Hughes, Eddy Arnold

Journal:

The International Journal of Biochemistry & Cell Biology

Année:

2004

Langue:

english

Fichier:

PDF, 323 KB

english, 2004

24

2′-Deoxy-4′-C-ethynyl-2-halo-adenosines active against drug-resistant human immunodeficiency virus type 1 variants

Atsushi Kawamoto, Eiichi Kodama, Stefan G. Sarafianos, Yasuko Sakagami, Satoru Kohgo, Kenji Kitano, Noriyuki Ashida, Yuko Iwai, Hiroyuki Hayakawa, Hirotomo Nakata, Hiroaki Mitsuya, Eddy Arnold, Masao

Journal:

The International Journal of Biochemistry & Cell Biology

Année:

2008

Langue:

english

Fichier:

PDF, 796 KB

english, 2008

25

Rev-derived peptides inhibit HIV-1 replication by antagonism of Rev and a co-receptor, CXCR4

Kazuki Shimane, Eiichi N. Kodama, Ikuhiko Nakase, Shiroh Futaki, Yasuteru Sakurai, Yasuko Sakagami, Xiaoguang Li, Toshio Hattori, Stefan G. Sarafianos, Masao Matsuoka

Journal:

The International Journal of Biochemistry & Cell Biology

Année:

2010

Langue:

english

Fichier:

PDF, 753 KB

english, 2010

26

Antiviral therapies: Focus on hepatitis B reverse transcriptase

Eleftherios Michailidis, Karen A. Kirby, Atsuko Hachiya, Wangdon Yoo, Sun Pyo Hong, Soo-Ok Kim, William R. Folk, Stefan G. Sarafianos

Journal:

The International Journal of Biochemistry & Cell Biology

Année:

2012

Langue:

english

Fichier:

PDF, 1.83 MB

english, 2012

27

Inhibition of Bacterial RNA Polymerase by Streptolydigin: Stabilization of a Straight-Bridge-Helix Active-Center Conformation

Steven Tuske, Stefan G. Sarafianos, Xinyue Wang, Brian Hudson, Elena Sineva, Jayanta Mukhopadhyay, Jens J. Birktoft, Olivier Leroy, Sajida Ismail, Arthur D. Clark Jr., Chhaya Dharia, Andrew Napoli, Ol

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 799 KB

english, 2005

28

The RNA Polymerase “Switch Region” Is a Target for Inhibitors

Jayanta Mukhopadhyay, Kalyan Das, Sajida Ismail, David Koppstein, Minyoung Jang, Brian Hudson, Stefan Sarafianos, Steven Tuske, Jay Patel, Rolf Jansen, Herbert Irschik, Eddy Arnold, Richard H. Ebright

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 804 KB

english, 2008

29

Identification of Amino Acid Residues in the Human Immunodeficiency Virus Type-1 Reverse Transcriptase Tryptophan-repeat Motif that are Required for Subunit Interaction Using Infectious Virions

Alok Mulky, Stefan G. Sarafianos, Yujiang Jia, Eddy Arnold, John C. Kappes

Journal:

Journal of Molecular Biology

Année:

2005

Langue:

english

Fichier:

PDF, 526 KB

english, 2005

30

Crystal Structures of Clinically Relevant Lys103Asn/Tyr181Cys Double Mutant HIV-1 Reverse Transcriptase in Complexes with ATP and Non-nucleoside Inhibitor HBY 097

Kalyan Das, Stefan G. Sarafianos, Arthur D. Clark Jr, Paul L. Boyer, Stephen H. Hughes, Eddy Arnold

Journal:

Journal of Molecular Biology

Année:

2007

Langue:

english

Fichier:

PDF, 1.11 MB

english, 2007

31

Expression and purification of SARS coronavirus proteins using SUMO-fusions

Xun Zuo, Michael R. Mattern, Robin Tan, Shuisen Li, John Hall, David E. Sterner, Joshua Shoo, Hiep Tran, Peter Lim, Stefan G. Sarafianos, Lubna Kazi, Sonia Navas-Martin, Susan R. Weiss, Tauseef R. But

Journal:

Protein Expression and Purification

Année:

2005

Langue:

english

Fichier:

PDF, 751 KB

english, 2005

32

HIV-1 Reverse Transcriptase Structure with RNase H Inhibitor Dihydroxy Benzoyl Naphthyl Hydrazone Bound at a Novel Site

Himmel, Daniel M., Sarafianos, Stefan G., Dharmasena, Sanjeewa, Hossain, Mohammed M., McCoy-Simandle, Kessler, Ilina, Tatiana, Clark, Arthur D., Knight, Jennifer L., Julias, John G., Clark, Patrick K.

Journal:

ACS Chemical Biology

Année:

2006

Langue:

english

Fichier:

PDF, 1.04 MB

english, 2006

33

Repeated exposure to 5D9, an inhibitor of 3D polymerase, effectively limits the replication of foot-and-mouth disease virus in host cells

Rai, Devendra K., Schafer, Elizabeth A., Singh, Kamalendra, McIntosh, Mark A., Sarafianos, Stefan G., Rieder, Elizabeth

Journal:

Antiviral Research

Année:

2013

Langue:

english

Fichier:

PDF, 1.17 MB

english, 2013

34

Preformulation studies of EFdA, a novel nucleoside reverse transcriptase inhibitor for HIV prevention

Zhang, Wei, Parniak, Michael A., Mitsuya, Hiroaki, Sarafianos, Stefan G., Graebing, Phillip W., Rohan, Lisa C.

Journal:

Drug Development and Industrial Pharmacy

Année:

2014

Langue:

english

Fichier:

PDF, 765 KB

english, 2014

35

Development of a vaginal delivery film containing EFdA, a novel anti-HIV nucleoside reverse transcriptase inhibitor

Zhang, Wei, Parniak, Michael A., Sarafianos, Stefan G., Cost, Marilyn R., Rohan, Lisa C.

Journal:

International Journal of Pharmaceutics

Année:

2014

Langue:

english

Fichier:

PDF, 1.97 MB

english, 2014

36

Probing the molecular mechanism of action of the HIV-1 reverse transcriptase inhibitor 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) using pre-steady-state kinetics

Muftuoglu, Yagmur, Sohl, Christal D., Mislak, Andrea C., Mitsuya, Hiroaki, Sarafianos, Stefan G., Anderson, Karen S.

Journal:

Antiviral Research

Année:

2014

Langue:

english

Fichier:

PDF, 678 KB

english, 2014

37

Lamivudine (3TC) Resistance in HIV-1 Reverse Transcriptase Involves Steric Hindrance with β -Branched Amino Acids

Stefan G. Sarafianos, Kalyan Das, Arthur D. Clark, Jr., Jianping Ding, Paul L. Boyer, Stephen H. Hughes and Edward Arnold

Journal:

Proceedings of the National Academy of Sciences

Année:

1999

Langue:

english

Fichier:

PDF, 1.72 MB

english, 1999

38

In vitro transport characteristics of EFdA, a novel nucleoside reverse transcriptase inhibitor using Caco-2 and MDCKII cell monolayers

Zhang, Wei, Parniak, Michael A., Sarafianos, Stefan G., Empey, Philip E., Rohan, Lisa C.

Journal:

European Journal of Pharmacology

Année:

2014

Langue:

english

Fichier:

PDF, 499 KB

english, 2014

39

Synthesis of AZTp S p CX2 pp S A and AZTp S p CX2 pp S AZT: Hydrolysis-Resistant Potential Inhibitors of the AZT Excision Reaction of HIV-1 RT

Han, Qianwei, Sarafianos, Stefan G., Arnold, Eddy, Parniak, Michael A., Gaffney, Barbara L., Jones, Roger A.

Journal:

Organic Letters

Année:

2007

Langue:

english

Fichier:

PDF, 64 KB

english, 2007

40

Interactions of Conformationally Biased North and South 2‘-Fluoro-2‘,3‘-dideoxynucleoside 5‘-Triphosphates with the Active Site of HIV-1 Reverse Transcriptase

Mu, Lan, Sarafianos, Stefan G., Nicklaus, Marc C., Russ, Pamela, Siddiqui, Maqbool A., Ford, Harry, Mitsuya, Hiroaki, Le, Richard, Kodama, Eiichi, Meier, Chris, Knispel, Tina, Anderson, Lynne, Barchi,

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 723 KB

english, 2000

41

Antiviral drugs specific for coronaviruses in preclinical development

Adedeji, Adeyemi O, Sarafianos, Stefan G

Journal:

Current Opinion in Virology

Année:

2014

Langue:

english

Fichier:

PDF, 930 KB

english, 2014

42

Introducing Our Authors

Hang, Howard C., Warthaka, Mangalika, Worthington, Andrew, Sayut, Daniel J., Himmel, Daniel M., Sarafianos, Stefan G.

Journal:

ACS Chemical Biology

Année:

2006

Langue:

english

Fichier:

PDF, 676 KB

english, 2006

43

3‘-Azido-3‘-deoxythymidine-(5‘)-tetraphospho-(5‘)-adenosine, the Product of ATP-Mediated Excision of Chain-Terminating AZTMP, Is a Potent Chain-Terminating Substrate for HIV-1 Reverse Transcriptase †

Dharmasena, Sanjeewa, Pongracz, Zita, Arnold, Eddy, Sarafianos, Stefan G., Parniak, Michael A.

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 244 KB

english, 2007

44

Design, Synthesis, Biochemical, and Antiviral Evaluations of C6 Benzyl and C6 Biarylmethyl Substituted 2-Hydroxylisoquinoline-1,3-diones: Dual Inhibition against HIV Reverse Transcriptase-Associated RNase H and Polymerase with Antiviral Activities

Vernekar, Sanjeev Kumar V., Liu, Zheng, Nagy, Eva, Miller, Lena, Kirby, Karen A., Wilson, Daniel J., Kankanala, Jayakanth, Sarafianos, Stefan G., Parniak, Michael A., Wang, Zhengqiang

Journal:

Journal of Medicinal Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 1.13 MB

english, 2015

45

CODAS Syndrome Is Associated with Mutations of LONP1, Encoding Mitochondrial AAA+ Lon Protease

Strauss, Kevin A., Jinks, Robert N., Puffenberger, Erik G., Venkatesh, Sundararajan, Singh, Kamalendra, Cheng, Iteen, Mikita, Natalie, Thilagavathi, Jayapalraja, Lee, Jae, Sarafianos, Stefan, Benkert,

Journal:

The American Journal of Human Genetics

Année:

2015

Langue:

english

Fichier:

PDF, 2.49 MB

english, 2015

46

Structural requirements for RNA degradation by HIV-1 reverse transcriptase

Das, Kalyan, Sarafianos, Stefan G, Arnold, Eddy

Journal:

Nature Structural and Molecular Biology

Année:

2013

Langue:

english

Fichier:

PDF, 783 KB

english, 2013

47

Structural Determinants of Slippage-mediated Mutations by Human Immunodeficiency Virus Type 1 Reverse Transcriptase

Hamburgh, Monica E., Curr, Kenneth A., Monaghan, Melissa, Rao, Vasudev R., Tripathi, Snehlata, Preston, Bradley D., Sarafianos, Stefan, Arnold, Eddy, Darden, Thomas, Prasad, Vinayaka R.

Journal:

Journal of Biological Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 880 KB

english, 2006

48

Vaginal Microbicide Film Combinations of Two Reverse Transcriptase Inhibitors, EFdA and CSIC, for the Prevention of HIV-1 Sexual Transmission

Zhang, Wei, Hu, Minlu, Shi, Yuan, Gong, Tiantian, Dezzutti, Charlene S., Moncla, Bernard, Sarafianos, Stefan G., Parniak, Michael A., Rohan, Lisa C.

Journal:

Pharmaceutical Research

Année:

2015

Langue:

english

Fichier:

PDF, 3.00 MB

english, 2015

49

Multifunctionality of a Picornavirus Polymerase Domain: Nuclear Localization Signal and Nucleotide Recognition

Ferrer-Orta, Cristina, de la Higuera, Ignacio, Caridi, Flavia, Sánchez-Aparicio, María Teresa, Moreno, Elena, Perales, Celia, Singh, Kamalendra, Sarafianos, Stefan G., Sobrino, Francisco, Domingo, Est

Journal:

Journal of Virology

Année:

2015

Fichier:

PDF, 6.66 MB

2015

50

Fast Hepatitis C Virus RNA Elimination and NS5A Redistribution by NS5A Inhibitors Studied by a Multiplex Assay Approach

Liu, Dandan, Ji, Juan, Ndongwe, Tanya P., Michailidis, Eleftherios, Rice, Charles M., Ralston, Robert, Sarafianos, Stefan G.

Journal:

Antimicrobial Agents and Chemotherapy

Année:

2015

Langue:

english

Fichier:

PDF, 3.52 MB

english, 2015